Learn more about the SIRT1 gene, or "skinny gene," by visiting our e-store and purchasing The Alternate-Day Diet.






SIRT1 to the Rescue – Why the Johnson UpDayDownDay Diet™ Works 

If you have tried other diets and experienced frustration and disappointment with the results, you may be wondering how the Johnson UpDayDownDay Diet™ is different. Why is the plan so effective in helping people lose weight and, more importantly, keeping that weight off? How does the diet help slow the aging process, reduce the risk of inflammatory disease, and offer other such remarkable benefits? The answers lie in the activation of SIRT1, the "skinny gene" that can be turned on by both an alternate-day calorie restriction diet and resveratrol.

What is SIRT1?

SIRT1 is a gene found in humans and other mammals that helps to promote survival by protecting cells during times when food (and therefore energy) is scarce. Scientists have discovered similar genes in almost all species, including Sir2 in yeast, worms, and fruit flies.

SIRT1 acts as a "rescue gene," repairing the damage done by free radicals and preventing cells from dying prematurely. The gene also causes mitochondria, the power plants of cells, to produce energy at higher levels that are typically associated with younger cells. As a result, SIRT1 is believed to be a principal regulator of lifespan.

The Benefits of SIRT1

The SIRT1 gene, or "skinny gene," assists with weight loss by inhibiting fat storage and increasing fat metabolism. By causing the body to store fewer fat cells, SIRT1 can also slow the aging process by reducing the risk of age-related diseases and health threats, including heart attack and stroke, diabetes, arthritis, and osteoporosis. These conditions have all been linked to an excess amount of fat cells in the body.

In addition, SIRT1 can reduce markers of inflammation and oxidative stress, two other primary causes of aging. Studies show that individuals who live to be 100 years old have lower levels of oxidative stress, meaning fewer free radical cells, than those who live to be 70. Oxidative stress is also thought to be a more reliable indicator of heart disease than cholesterol levels or other factors. In his study on asthma patients, Dr. Johnson showed how restricting calories on alternate days can raise SIRT1 levels and reduce symptoms associated with inflammation.

Dr. Johnson continues to study the effects of SIRT1 and exactly how its benefits are conveyed.

How is the gene activated?

SIRT1 is activated by calorie restriction or by the compound in red wine known as resveratrol. Dr. James Johnson developed the UpDayDownDay Diet™, a method of alternate-day calorie restriction, so that individuals can receive the benefits from "turning on" the SIRT1 gene while losing weight at the same time.

The body's response to calorie restriction is an example of "hormesis," in which a normally dangerous stressor can actually be beneficial in small amounts. Although an animal will die if it starves, moderate calorie restriction can actually increase its chances of survival by raising levels of SIRT1.

Learn More about the SIRT1 "Skinny Gene" and the Johnson UpDayDownDay Diet™

In his book, Dr. Johnson describes the anti-aging, anti-disease, and weight loss benefits of the UpDayDownDay Diet™. You can also purchase resveratrol to activate your SIRT1 gene, or "skinny" gene, without going on a calorie restricted diet.

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